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This occurs through several potential mechanisms: IGF-1 stimulates collagen synthesis and cartilage matrix expansion Growth signalling in synovial tissue may increase fluid production Systemic effects on sodium and water handling This side effect is typically mild and reversible

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Mechanism: Increased satiety signalling Delayed gastric emptying Reduced caloric intake It does not directly influence glucagon-mediated energy output

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Not all selenoproteins are affected by selenium concentration to the same extent as GPx1